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Prevalence in the United States of aac(6 ′ ) - Ib - cr Encoding a Ciprofloxacin-Modifying Enzyme

Antimicrobial Agents and Chemotherapy · 2006 · Vol. 50(11) · pp. 3953–3955

Chi Hye Park(Massachusetts General Hospital)Ari Robicsek(NorthShore University HealthSystem)George A. Jacoby(Lahey Hospital and Medical Center)Daniel F. SahmDavid C. Hooper✉(Massachusetts General Hospital)

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Abstract

Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.

Antibiotic Resistance in Bacteria Mycobacterium research and diagnosis Antimicrobial Resistance in StaphylococcusCiprofloxacinCeftazidimeEnterobacteriaceaeMicrobiologyEscherichia coliBiologyAntibacterial agentAntibioticsGeneBacteria

MeSH terms

AcetyltransferasesAnti-Bacterial AgentsCiprofloxacinCross-Sectional StudiesEnterobacteriaceaeEnterobacteriaceae InfectionsEscherichia coliKlebsiella pneumoniaeMicrobial Sensitivity TestsUnited StatesOdds RatioDrug Resistance, Bacterial