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Antimicrobial Resistance in ESKAPE Pathogens

Clinical Microbiology Reviews · 2020 · Vol. 33(3)

David M. P. De Oliveira✉(The University of Queensland)Brian M. Forde(The University of Queensland)Timothy J. Kidd(The University of Queensland)Patrick N. A. Harris(The University of Queensland)Mark A. Schembri(The University of Queensland)Scott A. Beatson(The University of Queensland)David L. Paterson(The University of Queensland)Mark J. Walker(The University of Queensland)

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Abstract

Antimicrobial-resistant ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antimicrobial resistance surveillance. This looming health threat has restimulated interest in the development of new antimicrobial therapies, has demanded the need for better patient care, and has facilitated heightened governance over stewardship practices.

Antibiotic Resistance in Bacteria Bacterial Identification and Susceptibility Testing Antibiotic Use and ResistanceAntimicrobialAntibiotic resistanceMicrobiologyKlebsiella pneumoniaeDrug resistanceBiologyMedicineAntibioticsGeneEscherichia coli