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Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Molecular Psychiatry · 2007 · Vol. 13(7) · pp. 717–728
Inbal GoshenTirzah KreiselO Ben-Menachem-ZidonTamar LichtJoseph WeidenfeldTamir Ben‐HurRaz Yirmiya
Stress Responses and CortisolTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsNeurogenesisEndocrinologyInternal medicineCorticosteroneHippocampal formationHippocampusDoublecortinChronic stressDentate gyrusMedicine

MeSH terms

Adrenal CortexAnimalsBrainBromodeoxyuridineChronic DiseaseDepressionEnzyme-Linked Immunosorbent AssayHippocampusInterleukin-1Mice, Inbred C57BLMice, TransgenicStress, PsychologicalReceptors, Interleukin-1Mice, KnockoutMice

Funding

  • Hebrew University of Jerusalem
  • Israel Science Foundation
Citations
755
FWCI
6.79
field-weighted impact
References
84
Percentile
99%
vs. same field & year
Citations per year
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Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression · Scinovex