reviewTop 1% cited
Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway
Current Opinion in Neurobiology · 2001 · Vol. 11(3) · pp. 297–305
Anne Brunet✉(Boston Children's Hospital)Sandeep Robert Datta✉(Harvard University)Michael E. Greenberg✉(Harvard University)
Cell death mechanisms and regulationPI3K/AKT/mTOR signaling in cancerFOXO transcription factor regulationProtein kinase BPI3K/AKT/mTOR pathwayBiologyProgrammed cell deathSignal transductionTranscription factorCell biologyCell survivalGeneApoptosis
MeSH terms
AnimalsGene Expression RegulationMultigene FamilyHumansMammalsModels, NeurologicalNerve Growth FactorsNerve Tissue ProteinsNeuronsNuclear ProteinsPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene ProteinsTranscription FactorsTranscription, Genetic
Funding
- National Institutes of Health
Citations
1,181
FWCI
21.99
field-weighted impact
References
86
Percentile
100%
vs. same field & year
Citations per year
Cited by
Neurotrophin Peptidomimetics: A new era in precision neurology and drug development
International Journal of Pharmaceutical Research and Development · 2025 · 0 citations
Neurotrophin-regulated signalling pathways
Philosophical Transactions of the Royal Society B Biological Sciences · 2006 · 2,154 citations
Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium
Neuropharmacology · 2002 · 433 citations
Forkhead Transcription Factors: Key Players in Development and Metabolism
Developmental Biology · 2002 · 847 citations
The ErbB receptors and their role in cancer progression
Experimental Cell Research · 2003 · 611 citations
References
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
Current Biology · 2000 · 965 citations
The PI3K–PDK1 connection: more than just a road to PKB
Biochemical Journal · 2000 · 1,590 citations
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell · 1997 · 5,689 citations
BCL-2 family members and the mitochondria in apoptosis
Genes & Development · 1999 · 3,645 citations
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell · 1999 · 6,532 citations
IAP family proteins---suppressors of apoptosis
Genes & Development · 1999 · 2,549 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.