article Open AccessTop 10% cited

Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

Journal of Pharmacology and Experimental Therapeutics · 2002 · Vol. 302(2) · pp. 645–650

Rajinder Bhardwaj✉(Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology)Hartmut GlaeserLaurent BecquemontUlrich KlotzSuresh Kumar GuptaMartin F. Fromm

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Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Piperaceae Chemical and Biological StudiesPiperineCYP3A4ChemistryGrapefruit juicePharmacologyP-glycoproteinPharmacokineticsBiochemistryEnzymeCytochrome P450

MeSH terms

AlkaloidsBiological TransportColonic NeoplasmsDigoxinDose-Response Relationship, DrugEnzyme InhibitorsHumansMixed Function OxygenasesKineticsPiperidinesTumor Cells, CulturedCyclosporineATP Binding Cassette Transporter, Subfamily B, Member 1Cytochrome P-450 CYP3ABenzodioxoles

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524

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91%

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