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Effects on Coronary Heart Disease of Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

PLoS Medicine · 2010 · Vol. 7(3) · pp. e1000252–e1000252
Dariush MozaffarianRenata MichaSarah Wallace

Abstract

These findings provide evidence that consuming PUFA in place of SFA reduces CHD events in RCTs. This suggests that rather than trying to lower PUFA consumption, a shift toward greater population PUFA consumption in place of SFA would significantly reduce rates of CHD. Please see later in the article for the Editors' Summary.

Fatty Acid Research and HealthCardiovascular Disease and AdiposityNatural Products and Biological ResearchMeta-analysisPolyunsaturated fatMedicineRandomized controlled trialCoronary heart diseaseSaturated fatSystematic reviewInternal medicineClinical trialPolyunsaturated fatty acid

MeSH terms

Coronary DiseaseDietary FatsFatty AcidsFatty Acids, UnsaturatedFeeding BehaviorHumansMeta-Analysis as TopicRandomized Controlled Trials as Topic

Funding

  • Bill and Melinda Gates Foundation
  • Chicago Community Trust
  • GlaxoSmithKline
  • World Health Organization
  • National Institutes of Health
  • U.S. Food and Drug Administration
  • National Heart, Lung, and Blood Institute
Citations
1,203
FWCI
62.37
field-weighted impact
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49
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