articleTop 1% cited
Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation
Molecular Pharmacology · 2005 · Vol. 69(1) · pp. 195–206
Sita Aggarwal✉Haruyo Ichikawa(The University of Texas MD Anderson Cancer Center)Yasunari Takada(The University of Texas MD Anderson Cancer Center)Santosh K. Sandur(The University of Texas MD Anderson Cancer Center)Shishir Shishodia(The University of Texas MD Anderson Cancer Center)Bharat B. Aggarwal(The University of Texas MD Anderson Cancer Center)
Curcumin's Biomedical ApplicationsNatural product bioactivities and synthesisSynthesis and biological activityCurcuminProtein kinase BKinaseCancer researchChemistryCell biologyCell growthDownregulation and upregulationSignal transductionGene
MeSH terms
Base SequenceCurcuminEnzyme ActivationHumansImmunohistochemistryNeoplasm MetastasisPhosphorylationBlotting, WesternDown-RegulationNF-kappa BApoptosisGenes, ReporterDNA PrimersProtein TransportElectrophoretic Mobility Shift Assay
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References
Nuclear factor-κB
Cancer Cell · 2004 · 1,564 citations
Nuclear transcription factor-κB as a target for cancer drug development
Leukemia · 2002 · 438 citations
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
Molecular and Cellular Biology · 1999 · 1,298 citations
Natural Products as Sources of New Drugs over the Period 1981−2002
Journal of Natural Products · 2003 · 3,082 citations
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