articleTop 1% cited
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Neuropharmacology · 2005 · Vol. 49(7) · pp. 1053–1066
Qijiang Yan(St. Luke's-Roosevelt Hospital Center)Mustapha Rammal(Roosevelt Institute)Michael R. Tranfaglia(Fraxa Research Foundation)Robert Bauchwitz✉(Columbia University)
Genetics and Neurodevelopmental DisordersUbiquitin and proteasome pathwaysAutism Spectrum Disorder ResearchMetabotropic glutamate receptor 5Metabotropic glutamate receptorFragile X syndromeFMR1Metabotropic receptorMetabotropic glutamate receptor 1AntagonistKnockout mousePhenotypeAllele
MeSH terms
AgingAllelesAnimalsDrug SynergismExploratory BehaviorFemaleFragile X SyndromeGenotypeMaleMice, Inbred C57BLPhenotypePyridinesReceptors, Metabotropic GlutamateEpilepsy, ReflexMice
Funding
- FRAXA Research Foundation
Citations
523
FWCI
13.69
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References
62
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99%
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References
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Pharmacology Biochemistry and Behavior · 1986 · 1,524 citations
The mGluR theory of fragile X mental retardation
Trends in Neurosciences · 2004 · 1,587 citations
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