articleTop 1% cited

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

Neuropharmacology · 1999 · Vol. 38(10) · pp. 1493–1503

F. Gasparini(Novartis (Switzerland))Kurt Lingenhöhl(Novartis (Switzerland))Natacha Stoehr(Novartis (Switzerland))Peter J. Flor(Novartis (Switzerland))Micheline Heinrich(Novartis (Switzerland))Ivo Vranesic(Novartis (Switzerland))Michel Biollaz(Novartis (Switzerland))Hans Allgeier(Novartis (Switzerland))Roland Heckendorn(Novartis (Switzerland))Stephan Urwyler(Novartis (Switzerland))Mark A. VarneyEdwin C. JohnsonStephen D. HessSara RaoAida SacaanEmily M. SantoriGönül VeliçelebiRainer Kühn✉(Novartis (Switzerland))

View via DOI Publisher page

Neuroscience and Neuropharmacology Research Photoreceptor and optogenetics research Ion channel regulation and functionAgonistMetabotropic receptorPharmacologyAMPA receptorKainate receptorChemistryReceptor antagonistAntagonistReceptorMetabotropic glutamate receptor

MeSH terms

Cyclic AMPAnimalsAnimals, NewbornBrainCell LineHumansMaleMethoxyhydroxyphenylglycolOocytesPhosphatidylinositolsPyridinesRadioligand AssayRats, Inbred StrainsRecombinant ProteinsSulfur Radioisotopes

Citations

720

FWCI

12.88

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

Neuropharmacology · 1999 · 1,055 citations

Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation

Nature Neuroscience · 2002 · 1,453 citations

Ionotropic and metabotropic glutamate receptor structure and pharmacology

Psychopharmacology · 2005 · 777 citations

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP

Neuropharmacology · 2005 · 523 citations

References

Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

Neuroscience Letters · 1993 · 519 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.