articleTop 1% cited

Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model

Journal of Medical Genetics · 2008 · Vol. 46(2) · pp. 94–102

Tina Bilousova(University of California, Riverside)Lorraine E. Dansie(University of California, Riverside)Mary Kim Ngo(University of California, Riverside)Jamie M. Aye(University of California, Riverside)Jonathan R. Charles(University of California, Riverside)Douglas W. Ethell✉(University of California, Riverside)Iryna M. Ethell✉(University of California, Riverside)

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Abstract

These findings establish minocycline as a promising therapeutic for the treatment of fragile X mental retardation.

Genetics and Neurodevelopmental Disorders Neurogenesis and neuroplasticity mechanisms Adenosine and Purinergic SignalingFMR1MinocyclineFragile X syndromeDendritic spineHippocampal formationNeuroscienceHippocampusElevated plus mazeMicrogliaPsychology

MeSH terms

AnimalsBehavior, AnimalDisease Models, AnimalFragile X SyndromeHippocampusMinocyclineMotor ActivityNeuronsMatrix Metalloproteinase 9Dendritic SpinesMiceFragile X Mental Retardation ProteinFragile X Messenger Ribonucleoprotein 1Gene Knockout Techniques

Citations

460

FWCI

18.68

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99%

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Cited by

Minocycline: far beyond an antibiotic