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Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

Immunity · 2006 · Vol. 25(6) · pp. 977–988
Tatsuki SugiyamaHiroshi KoharaMamiko NodaTakashi Nagasawa
Hematopoietic Stem Cell TransplantationChemokine receptors and signalingImmune Response and InflammationBiologyStromal cellBone marrowCell biologyHaematopoiesisCXCR4Stem cellStromal cell-derived factor 1Hematopoietic stem cellProgenitor cell

MeSH terms

AnimalsBone MarrowFlow CytometryHematopoietic Stem CellsImmunohistochemistryMice, Mutant StrainsSignal TransductionStromal CellsAdoptive TransferReceptors, CXCR4Chemokines, CXCReverse Transcriptase Polymerase Chain ReactionMiceChemokine CXCL12

Funding

  • Uehara Memorial Foundation
  • Ministry of Education, Culture, Sports, Science and Technology
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