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Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
Arthritis & Rheumatism · 1999 · Vol. 42(5) · pp. 963–970
Martine Chabaud(Hôpital Edouard Herriot)Jean Marc Durand(Hôpital Edouard Herriot)Nicolas C. Buchs(Hôpital Edouard Herriot)Fran�ois FossiezGuillaume Page(Hôpital Edouard Herriot)Lucien Frappart(Hôpital Edouard Herriot)Pierre Miossec✉(Hôpital Edouard Herriot)
Abstract
The T cell cytokine IL-17 was found to be highly produced by RA, but not by OA, synovium. Its production and function were down-regulated by IL-4 and IL-13. These results indicate that IL-17 contributes to the active, proinflammatory pattern that is characteristic of RA. Through the contribution of IL-17, some Th1-like T cells appear to mediate synovial inflammation.
Rheumatoid Arthritis Research and TherapiesToxin Mechanisms and ImmunotoxinsMonoclonal and Polyclonal Antibodies ResearchProinflammatory cytokineCytokineSynovial membraneInterleukinSynovial fluidMedicineImmunologyInterleukin 17Ex vivoImmunostaining
MeSH terms
Arthritis, RheumatoidHumansInterleukin-1RNA, MessengerSynovial MembraneT-LymphocytesInterleukin-4Interleukin-6Gene ExpressionCytokinesInterleukin-13Reverse Transcriptase Polymerase Chain ReactionInterleukin-17
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References
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The Journal of Experimental Medicine · 1996 · 1,507 citations
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Analytical Biochemistry · 1987 · 46,850 citations
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