article Open AccessTop 1% cited
Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons
American Journal Of Pathology · 1999 · Vol. 154(5) · pp. 1423–1429
Jing Zhang✉(Case Western Reserve University)George Perry(Case Western Reserve University)Mark A. Smith(Vanderbilt University Medical Center)David Robertson(Vanderbilt University Medical Center)Sandra J. Olson(Pharmacology Research Institute)Doyle G. Graham(Institute of Pharmacology)Thomas J. Montine(Vanderbilt University Medical Center)
Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and PathologyGenetic Neurodegenerative DiseasesSubstantia nigraParkinson's diseaseRNADiseaseOxidative stressBiologyPathologyNeuromelaninCytoplasmOxidative phosphorylation
MeSH terms
AgedCytoplasmDNAFemaleGuanosineHumansImmunohistochemistryMaleNeuronsParkinson DiseaseRNASubstantia NigraCell DeathHydroxyl RadicalOxidative Stress
Funding
- National Parkinson Foundation
- American Foundation for Aging Research
- University of Kentucky
- Parkinsonfonden
Citations
639
FWCI
13.30
field-weighted impact
References
43
Percentile
99%
vs. same field & year
Citations per year
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References
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Autoxidation versus Covalent Binding of Quinones as the Mechanism of Toxicity of Dopamine, 6-Hydroxydopamine, and Related Compounds toward C1300 Neuroblastoma Cells in Vitro
Molecular Pharmacology · 1978 · 956 citations
Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra
Journal of Neurochemistry · 1997 · 839 citations
Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones
Molecular Pharmacology · 1978 · 1,094 citations
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