article Open AccessTop 1% cited
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
Diabetologia · 2007 · Vol. 50(4) · pp. 752–763
D. Ross Laybutt✉(Garvan Institute of Medical Research)Amanda M. Preston(Garvan Institute of Medical Research)M. C. Åkerfeldt(St Vincent's Hospital Sydney)James G. Kench(Garvan Institute of Medical Research)Anna K. Busch(St Vincent's Hospital Sydney)Andrew V. Biankin(St Vincent's Hospital Sydney)Trevor J. Biden(Saint Vincent's Catholic Medical Center)
Pancreatic function and diabetesEndoplasmic Reticulum Stress and DiseaseDiabetes and associated disordersUnfolded protein responseEndoplasmic reticulumXBP1ApoptosisPancreatic isletsBiologyEndocrinologyHeat shock proteinInternal medicineDownregulation and upregulation
MeSH terms
Endoplasmic Reticulum Chaperone BiPAnimalsCell LineDiabetes Mellitus, Type 2Endoplasmic ReticulumGene Expression RegulationHeat-Shock ProteinsHumansLipidsMice, Inbred C57BLRNA, MessengerBlotting, WesternApoptosisOxidative StressMolecular Chaperones
Funding
- Diabetes Australia Research Trust
- Diabetes Australia
- Cancer Institute NSW
- Medical Research Council
- National Health and Medical Research Council
Citations
816
FWCI
53.34
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
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References
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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
Diabetologia · 2003 · 2,138 citations
Roles of CHOP/GADD153 in endoplasmic reticulum stress
Cell Death and Differentiation · 2003 · 2,809 citations
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Molecular Cell · 2001 · 1,342 citations
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
Annual Review of Biochemistry · 2005 · 3,009 citations
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Diabetes · 2003 · 3,966 citations
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Molecular Cell · 2000 · 3,216 citations
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