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Membrane transporters in drug development

Nature Reviews Drug Discovery · 2010 · Vol. 9(3) · pp. 215–236

Kathleen M. Giacomini✉(University of California, San Francisco)Shiew‐Mei Huang(United States Food and Drug Administration)Donald Tweedie(Boehringer Ingelheim (Brazil))Leslie Z. Benet(University of California, San Francisco)Kim L. R. BrouwerXiaoyan Chu(Merck (Japan))Amber Dahlin(University of California, San Francisco)Raymond Evers(Merck (Japan))Volker Fischer(Abbott (United Kingdom))Kathleen M. Hillgren(Eli Lilly (United States))Keith Hoffmaster(Novartis (United States))Toshihisa Ishikawa(RIKEN)Dietrich Keppler(German Cancer Research Center)Richard B. Kim(Western University)Caroline A. Lee(Pfizer (United States))Mikko Niemi(University of Helsinki)Joseph W. Polli(GlaxoSmithKline (Netherlands))Yuicchi Sugiyama(The University of Tokyo)Peter W. Swaan(University of Maryland, Baltimore)Joseph A. Ware(Acentech (United States))Stephen H. Wright(University of Arizona)Sook Wah Yee(University of California, San Francisco)Maciej J. Zamek‐Gliszczynski(Eli Lilly (United States))Lei Zhang(United States Food and Drug Administration)

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Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies HIV/AIDS drug development and treatmentDrug developmentDrugTransporterDrug discoveryPharmacologyChemistryComputational biologyMedicineBiologyBiochemistry

MeSH terms

AnimalsComputer SimulationDecision TreesDrug InteractionsDrug Evaluation, PreclinicalHumansDrug ApprovalMice, KnockoutMembrane Transport ProteinsMicePrescription DrugsDrug Discovery