articleTop 10% cited
Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters
Pharmaceutical Research · 2008 · Vol. 26(1) · pp. 139–151
Patrick J. Marsac✉(United States Military Academy)Tonglei Li(University of Kentucky)Lynne S. Taylor(Purdue University West Lafayette)
Analytical Chemistry and ChromatographyDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesMelting-point depressionMiscibilitySolubilityAmorphous solidThermodynamicsFlory–Huggins solution theoryEntropy of mixingPolymerHildebrand solubility parameterDifferential scanning calorimetry
MeSH terms
Chemistry, PharmaceuticalCrystallizationPharmaceutical PreparationsHydrogen BondingMolecular WeightPolymersSolubilityTemperatureThermodynamics
Funding
- Pharmaceutical Research and Manufacturers of America Foundation
- AstraZeneca
- American Association of Colleges of Pharmacy
Citations
491
FWCI
8.05
field-weighted impact
References
80
Percentile
98%
vs. same field & year
Citations per year
Cited by
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References
An introduction to hydrogen bonding
Choice Reviews Online · 1998 · 6,248 citations
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Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions
Pharmaceutical Research · 1997 · 887 citations
What is the True Solubility Advantage for Amorphous Pharmaceuticals?
Pharmaceutical Research · 2000 · 1,334 citations
Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
Journal of Pharmaceutical Sciences · 1999 · 1,638 citations
Solubility parameters as predictors of miscibility in solid dispersions
Journal of Pharmaceutical Sciences · 1999 · 659 citations
Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility
Pharmaceutical Research · 2006 · 573 citations
Melting Point Depression and Kinetic Effects of Cooling on Crystallization in Poly(vinylidene fluoride)-Poly(methyl methacrylate) Mixtures
Macromolecules · 1975 · 1,305 citations
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Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters
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