articleTop 1% cited

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

Brain Research · 1989 · Vol. 477(1-2) · pp. 90–99

C. Bancher✉(University of Vienna)Christof Brunner(University of Vienna)Hans Lassmann(Sigmund Freud University Vienna)Herbert Budka(Sigmund Freud University Vienna)K. A. Jellinger(Ludwig Boltzmann Institute for Digital Health and Prevention)Gerhard Wiche(University of Vienna)F Seitelberger(University of Vienna)Inge Grundke‐IqbalKhalid IqbalH. M. Wisniewski

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Alzheimer's disease research and treatments Ubiquitin and proteasome pathways Endoplasmic Reticulum Stress and DiseaseNeurofibrillary tangleTangleSenile plaquesNeurofilamentPathologyImmunocytochemistryAlzheimer's diseaseCytoskeletonTau proteinIntermediate filament

MeSH terms

AdultAgedAged, 80 and overAlzheimer DiseaseGlial Fibrillary Acidic ProteinHumansMicroscopy, ElectronMicrotubule-Associated ProteinsMiddle AgedNerve Tissue ProteinsNeurofibrilsPhosphorylationReference Valuestau Proteins

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810

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20.18

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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads