articleTop 1% cited
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
Biochemical and Biophysical Research Communications · 1989 · Vol. 159(2) · pp. 548–553
Eiji Kobayashi✉(Kyowa Kirin (Japan))Hirofumi Nakano(Kyowa Kirin (Japan))Makoto Morimoto(Kyowa Kirin (Japan))Tatsuya Tamaoki(Kyowa Kirin (Japan))
Marine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisChemical synthesis and alkaloidsCalphostin CCalphostinc-RafProtein kinase CCyclin-dependent kinase 9Mitogen-activated protein kinase kinaseProtein kinase ACyclin-dependent kinase 2MAP2K7Biochemistry
MeSH terms
AnimalsAntineoplastic AgentsCarrier ProteinsCell DivisionCladosporiumMitosporic FungiFungal ProteinsHeLa CellsHumansNaphthalenesPhorbol EstersPolycyclic CompoundsProtein Kinase CReceptors, DrugCaenorhabditis elegans Proteins
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1,115
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References
Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase
Biochemical and Biophysical Research Communications · 1986 · 2,458 citations
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
Journal of Biological Chemistry · 1982 · 4,754 citations
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C
Biochemistry · 1984 · 2,703 citations
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Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
Biochemical and Biophysical Research Communications · 1989 · 1,115 citations
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