reviewTop 1% cited
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Journal of Pharmaceutical Sciences · 1997 · Vol. 86(1) · pp. 1–12
Bruno C. Hancock✉George Zografi(University of Wisconsin–Madison)
Abstract
The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms. This review describes the characteristics of the amorphous state and some of the most common methods that can be used to measure them. Examples of pharmaceutical situations where the presence of the amorphous state plays an important role are presented. The application of our current knowledge to pharmaceutical formulation problems is illustrated, and some strategies for working with amorphous character in pharmaceutical systems are provided.
Drug Solubulity and Delivery SystemsMaterial Dynamics and PropertiesMicroencapsulation and Drying ProcessesAmorphous solidState (computer science)Pharmaceutical sciencesPharmaceutical technologyDosage formPharmaceutical industrySolid-stateBiochemical engineeringMaterials scienceComputer science
MeSH terms
Chemistry, PharmaceuticalCrystallizationX-Ray Diffraction
Citations
1,873
FWCI
31.28
field-weighted impact
References
124
Percentile
100%
vs. same field & year
Citations per year
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Journal of the American Chemical Society · 1955 · 7,817 citations
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