articleTop 10% cited

A Polymorphism of the μ‐Opioid Receptor Gene <i>(OPRM1)</i> and Sensitivity to the Effects of Alcohol in Humans

Alcoholism Clinical and Experimental Research · 2004 · Vol. 28(12) · pp. 1789–1795

Lara A. Ray(University of Colorado Boulder)Kent E. Hutchison✉(University of Colorado System)

Abstract

These findings may help to explain previous research suggesting that naltrexone is more effective among individuals with the G allele. A medication that reduces feelings of euphoria after alcohol consumption may be more successful among individuals with a genetic predisposition to greater feelings of euphoria after consuming alcohol.

Neuropeptides and Animal Physiology Neurotransmitter Receptor Influence on Behavior Pharmacology and Obesity TreatmentEuphoriantNaltrexoneAlleleAlcoholAlcohol intoxicationMedicineAlcohol use disorderMoodPsychologyAlcohol dependence

MeSH terms

AdultAffectAlcohol DrinkingEthanolAllelesBreath TestsFemaleHumansInfusions, IntravenousMalePolymorphism, GeneticChi-Square DistributionReceptors, Opioid, mu

Citations

317

FWCI

4.05

field-weighted impact

References

Percentile

95%

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Citations per year

References

Endogenous opioid systems and alcohol addiction