review Open AccessTop 1% cited
Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
Journal of Hepatology · 2014 · Vol. 62(3) · pp. 720–733
Michał Pawlak✉(European Genomic Institute for Diabetes)Philippe LefèbvreBart Staels(European Genomic Institute for Diabetes)
Liver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and CancerSteatohepatitisPeroxisome proliferator-activated receptorFatty liverLipid metabolismNuclear receptorPeroxisome proliferator-activated receptor alphaSteatosisTranscription factorFatty acid metabolismAlcoholic fatty liver
MeSH terms
AnimalsDisease Models, AnimalHumansInflammationLiver CirrhosisModels, StatisticalPPAR alphaLipogenesisLipid MetabolismMiceNon-alcoholic Fatty Liver Disease
Citations
1,508
FWCI
31.75
field-weighted impact
References
155
Percentile
100%
vs. same field & year
Citations per year
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References
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.
The EMBO Journal · 1996 · 1,176 citations
The PPARs: From Orphan Receptors to Drug Discovery
Journal of Medicinal Chemistry · 2000 · 1,799 citations
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
Genes & Development · 2000 · 1,683 citations
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Journal of Clinical Investigation · 1999 · 1,632 citations
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Arteriosclerosis Thrombosis and Vascular Biology · 2000 · 3,128 citations
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Cell Metabolism · 2007 · 1,463 citations
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