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Carbonic anhydrase IX in oligodendroglial brain tumors
BMC Cancer · 2008 · Vol. 8(1) · pp. 1–1
Sally Järvelä✉(Tampere University Hospital)Seppo Parkkila(Tampere University)Helena Bragge(Tampere University Hospital)Marketta Kähkönen(Tampere University)Anna‐Kaisa Parkkila(Tampere University Hospital)Ylermi Soini(University of Oulu)Silvia Pastoreková(Institute of Virology of the Slovak Academy of Sciences)Jaromı́r Pastorek(Slovak Academy of Sciences)Hannu Haapasalo(Tampere University)
Abstract
CA IX was proved to be an independent prognostic indicator in oligodendroglial brain tumors, and it also correlates reversely with cell proliferation. It may have a role in the biology of oligodendrogliomas, and most interestingly, as it is mainly expressed in tumor tissue, CA IX could serve as a target molecule for anticancer treatments.
Enzyme function and inhibitionCancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation MechanismsCarbonic anhydraseOligodendrogliomaOligodendroglial TumorImmunohistochemistryCancer researchBrain tumorEnzymePathologyMedicineInternal medicine
MeSH terms
Carbonic Anhydrase IXAdultAntigens, NeoplasmBrain NeoplasmsCarbonic AnhydrasesFollow-Up StudiesHumansOligodendrogliomaSurvival RateCell Proliferation
Funding
- Academy of Finland
- Suomen Kulttuurirahasto
- Tays
Citations
293
FWCI
6.76
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53
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98%
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References
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Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
Bioorganic & Medicinal Chemistry Letters · 2003 · 257 citations
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