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Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
Bioorganic & Medicinal Chemistry Letters · 2003 · Vol. 14(1) · pp. 217–223
Francesco Abbate(University of Florence)Angela Casini(University of Florence)Takashi Owa✉(Eisai (Japan))Andrea Scozzafava(University of Florence)Claudiu T. Supuran✉(University of Florence)
Enzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and ActivitiesChemistryCarbonic anhydraseIsozymeAcetazolamideSulfonamideActive siteEnzymeStereochemistryEnzyme inhibitorCytosol
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