reviewTop 10% cited

Camptothecin: current perspectives

Bioorganic & Medicinal Chemistry · 2004 · Vol. 12(7) · pp. 1585–1604

Craig J. Thomas✉(University of Virginia)Nicolas J. Rahier(University of Virginia)Sidney M. Hecht(University of Virginia)

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Cancer therapeutics and mechanisms Bioactive Compounds and Antitumor Agents Synthesis and biological activityCamptothecinTopoisomeraseChemistryMechanism of actionDNAPharmacologyStereochemistryBiochemistryIn vitroBiology

MeSH terms

AnimalsAntineoplastic AgentsCamptothecinCell DivisionDNADNA Topoisomerases, Type IHumansStructure-Activity RelationshipMolecular StructureCell Line, TumorTopoisomerase I Inhibitors

Citations

437

FWCI

9.37

field-weighted impact

References

221

Percentile

99%

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Citations per year

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References

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Journal of Biological Chemistry · 1985 · 2,338 citations

Reduction of natural enones in the presence of cerium trichloride

Journal of the Chemical Society Chemical Communications · 1978 · 302 citations

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

Chemical and Pharmaceutical Bulletin · 1991 · 232 citations

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Journal of Pharmaceutical Sciences · 1992 · 462 citations

DNA Topoisomerases: Structure, Function, and Mechanism

Annual Review of Biochemistry · 2001 · 2,695 citations

DNA TOPOISOMERASES

Annual Review of Biochemistry · 1996 · 1,818 citations

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