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A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Journal of Pharmaceutical Sciences · 1992 · Vol. 81(7) · pp. 676–684
Julianne FassbergValentino J. Stella
Cancer therapeutics and mechanismsAntibiotics Pharmacokinetics and EfficacyDNA and Nucleic Acid ChemistryChemistryLactoneCarboxylateHydrolysisReaction rate constantEquilibrium constantHydroxideAqueous solutionStereochemistryRing (chemistry)

MeSH terms

AlgorithmsBuffersCamptothecinChromatography, High Pressure LiquidHydrogen-Ion ConcentrationHydrolysis
Citations
462
FWCI
2.15
field-weighted impact
References
13
Percentile
88%
vs. same field & year
Citations per year
Cited by
Camptothecin: current perspectives
Bioorganic & Medicinal Chemistry · 2004 · 437 citations
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A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues · Scinovex