review Open AccessTop 1% cited
The Role of Apolipoprotein E in Alzheimer's Disease
Neuron · 2009 · Vol. 63(3) · pp. 287–303
Jungsu Kim✉(Hope Center for Neurological Disorders)Jacob M. Basak(Hope Center for Neurological Disorders)David M. Holtzman(Hope Center for Neurological Disorders)
Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsApolipoprotein ENeuroinflammationNeuroscienceAlleleNeurotoxicityPathogenesisNeuroprotectionAlzheimer's diseaseDiseaseBiology
MeSH terms
Alzheimer DiseaseAnimalsApolipoproteins EBrainHumansModels, BiologicalMutationAmyloid beta-PeptidesMice
Funding
- American Health Assistance Foundation
- National Institutes of Health
Citations
1,622
FWCI
54.32
field-weighted impact
References
250
Percentile
100%
vs. same field & year
Citations per year
Cited by
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Science Translational Medicine · 2011 · 1,172 citations
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
Molecules · 2020 · 2,526 citations
Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease
Journal of Cerebral Blood Flow & Metabolism · 2015 · 619 citations
Alzheimer’s Disease: The Challenge of the Second Century
Science Translational Medicine · 2011 · 1,414 citations
Blood-Brain Barrier: From Physiology to Disease and Back
Physiological Reviews · 2018 · 2,072 citations
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Nature Reviews Drug Discovery · 2011 · 2,182 citations
Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
Biological Psychiatry · 2014 · 1,338 citations
Molecular mechanisms of neurodegeneration in Alzheimer's disease
Human Molecular Genetics · 2010 · 756 citations
References
Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
Neuroscience Letters · 1992 · 800 citations
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Nature Reviews Molecular Cell Biology · 2007 · 4,679 citations
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease
JAMA · 1997 · 4,580 citations
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Neuron · 2008 · 3,202 citations
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ <sub>42</sub> in humans
Annals of Neurology · 2005 · 1,247 citations
Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
The Lancet Neurology · 2008 · 1,224 citations
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proceedings of the National Academy of Sciences · 1993 · 4,266 citations
Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System
Journal of Cerebral Blood Flow & Metabolism · 2006 · 667 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.