reviewTop 1% cited
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
Analytical and Bioanalytical Chemistry · 2008 · Vol. 392(6) · pp. 1093–1108
Ulrich M. Zanger✉(University of Tübingen)Miia Turpeinen(University of Tübingen)Kathrin Klein(University of Tübingen)Matthias Schwab(University of Tübingen)
Pharmacogenetics and Drug MetabolismEicosanoids and Hypertension PharmacologyDrug Transport and Resistance MechanismsCYP2C19CYP2D6CYP1A2CYP2B6CYP2C9PharmacologyPharmacogeneticsCYP3A4Cytochrome P450Drug metabolism
MeSH terms
Adrenergic beta-AntagonistsBiotransformationCytochrome P-450 Enzyme SystemGenotypeHumansMutationPharmacogeneticsPhenotypePsychotropic DrugsTechnology, PharmaceuticalDrug DesignPolymorphism, Single NucleotideGenomicsProton Pump Inhibitors
Funding
- Robert Bosch Stiftung
Citations
589
FWCI
51.63
field-weighted impact
References
252
Percentile
100%
vs. same field & year
Citations per year
References
Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
British Journal of Clinical Pharmacology · 1999 · 746 citations
Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
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Clinical Pharmacology & Therapeutics · 2006 · 478 citations
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
Clinical Pharmacology & Therapeutics · 2006 · 723 citations
Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
Clinical Pharmacology & Therapeutics · 2003 · 654 citations
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
Nature Genetics · 2001 · 2,152 citations
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