article Open AccessTop 1% cited
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
International Journal of Obesity · 2014 · Vol. 39(3) · pp. 424–429
Arianna Psichas✉(Imperial College London)Michelle Sleeth(Imperial College London)Kevin G. Murphy(Imperial College London)Lucy Brooks(Imperial College London)Gavin A. Bewick(Imperial College London)Aylin C. Hanyaloglu(Imperial College London)Mohammad A. Ghatei(Imperial College London)Stephen R. Bloom(Imperial College London)Gary Frost(Imperial College London)
Abstract
Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo.
Regulation of Appetite and ObesityDiet and metabolism studiesBiochemical Analysis and Sensing TechniquesEndocrinologyPropionateInternal medicineShort-chain fatty acidFatty acidSecretionChemistryPeptide YYFree fatty acid receptor 1Receptor
MeSH terms
AnimalsColonGastrointestinal HormonesMice, Inbred C57BLPropionatesRats, WistarPeptide YYReceptors, G-Protein-CoupledMiceRatsGlucagon-Like Peptide 1
Funding
- National Institute for Health and Care Research
- Monash University
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- NIHR Imperial Biomedical Research Centre
- FP7 Health
Citations
813
FWCI
16.92
field-weighted impact
References
33
Percentile
100%
vs. same field & year
Citations per year
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References
Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters
Annals of Surgery · 2005 · 978 citations
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Journal of Biological Chemistry · 2003 · 2,311 citations
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Journal of Lipid Research · 2013 · 4,784 citations
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