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Epidermal Barrier Dysfunction in Atopic Dermatitis

Journal of Investigative Dermatology · 2009 · Vol. 129(8) · pp. 1892–1908

Michael J. Cork✉(University of Sheffield)Simon G. Danby(University of Sheffield)Yiannis Vasilopoulos(University of Sheffield)Jonathan Hadgraft(University of London)Majella E. Lane(University of London)Manar Moustafa(University of Sheffield)Richard H. Guy(University of Bath)Alice MacGowanRachid Tazi‐Ahnini(University of Sheffield)Simon Ward(University of Sheffield)

View via DOI Publisher page

Dermatology and Skin Diseases Food Allergy and Anaphylaxis Research Contact Dermatitis and AllergiesAtopic dermatitisDermatologySkin barrierMedicine

MeSH terms

Serine Peptidase Inhibitor Kazal-Type 5Filaggrin ProteinsAdrenal Cortex HormonesAnimalsDermatitis, AtopicDetergentsEpidermisHomeostasisHumansHydrogen-Ion ConcentrationKallikreinsMutationReceptor, Fibroblast Growth Factor, Type 1Proteinase Inhibitory Proteins, Secretory

Citations

751

FWCI

50.88

field-weighted impact

References

242

Percentile

100%

vs. same field & year

Citations per year

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References

Regional Variation in Percutaneous Penetration of 14C Cortisol in Man**From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122.

Journal of Investigative Dermatology · 1967 · 558 citations

Epidermal Lipids, Barrier Function, and Desquamation

Journal of Investigative Dermatology · 1983 · 1,347 citations

Degradation of Corneodesmosome Proteins by Two Serine Proteases of the Kallikrein Family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7

Journal of Investigative Dermatology · 2004 · 508 citations

The natural course of atopic dermatitis from birth to age 7 years and the association with asthma

Journal of Allergy and Clinical Immunology · 2004 · 796 citations

Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex (“Epidermal Differentiation Complex”) on Human Chromosome 1q21

Journal of Investigative Dermatology · 1996 · 502 citations

pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion

Journal of Investigative Dermatology · 2003 · 523 citations

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Nature Genetics · 2006 · 2,920 citations

Atopic dermatitis and the atopic march

Journal of Allergy and Clinical Immunology · 2003 · 1,210 citations

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