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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Nature Genetics · 2006 · Vol. 38(4) · pp. 441–446

Colin N A Palmer✉Alan D. Irvine(Our Lady's Hospital)Ana Terron-Kwiatkowski(University of Dundee)Yiwei Zhao(Ninewells Hospital)Haihui Liao(Ninewells Hospital)Simon P. Lee(Ninewells Hospital)David Goudie(Ninewells Hospital)Aileen Sandilands(Ninewells Hospital)Linda Campbell(Ninewells Hospital)Frances J.D. Smith(University of Dundee)Gráinne M. O’Regan(Children's Health Ireland at Crumlin)Rosemarie M. Watson(Our Lady's Hospital)Joanne E. Cecil(University of St Andrews)Sherri J. BaleJohn G. ComptonJohn J. DiGiovanna(Center for Cancer Research)Philip Fleckman(Seattle University)Sue Lewis‐Jones(Ninewells Hospital)Gehan Arseculeratne(Ninewells Hospital)Ann SergeantColin S. MunroBrahim El Houate(Institut Pasteur)Ken McElreavey(Institut Pasteur)Liselotte Brydensholt Halkjær(Copenhagen University Hospital)Hans Bisgaard(Copenhagen University Hospital)Somnath Mukhopadhyay(Ninewells Hospital)W.H. Irwin McLean(University of Dundee)

View via DOI Publisher page

Dermatology and Skin Diseases Allergic Rhinitis and Sensitization Food Allergy and Anaphylaxis ResearchFilaggrinAtopic dermatitisBiologyAsthmaAllergyImmunologyPopulationGenetic predispositionAtopyDisease

MeSH terms

Filaggrin ProteinsAllelesAsthmaChildDermatitis, AtopicFemaleHumansIntermediate Filament ProteinsMaleMutationPedigreeSkin Physiological PhenomenaCohort StudiesGenetic Predisposition to Disease

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References

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis..

British Journal of Dermatology · 1994 · 1,244 citations

The global burden of asthma: executive summary of the GINA Dissemination Committee Report

Allergy · 2004 · 3,554 citations

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation

British Journal of Dermatology · 1994 · 920 citations

Atopic dermatitis and the atopic march

Journal of Allergy and Clinical Immunology · 2003 · 1,210 citations

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