article Open AccessTop 1% cited

Tumor Progression While on Chemotherapy

Annals of Surgery · 2004 · Vol. 240(6) · pp. 1052–1064

René Adam✉(Hôpital Paul-Brousse)Gérard PascalDenis CastaingDaniel AzoulayV. DelvartBernard PauleFrançis LéviHenri Bismuth

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Abstract

Liver resection is able to offer long-term survival to patients with multiple colorectal metastases provided that the metastatic disease is controlled by chemotherapy prior to surgery. Tumor progression before surgery is associated with a poor outcome, even after potentially curative hepatectomy. Tumor control before surgery is crucial to offer a chance of prolonged remission in patients with multiple metastases.

Hepatocellular Carcinoma Treatment and Prognosis Colorectal Cancer Treatments and Studies Pancreatic and Hepatic Oncology ResearchMedicineOxaliplatinChemotherapyIrinotecanHepatectomySurgeryTumor progressionResectionColorectal cancerInternal medicine

MeSH terms

ContraindicationsIrinotecanOxaliplatinAntineoplastic Combined Chemotherapy ProtocolsCamptothecinLeucovorinEnzyme InhibitorsFemaleFluorouracilHepatectomyHumansLiver NeoplasmsMaleMiddle AgedOrganoplatinum Compounds

Citations

995

FWCI

24.71

field-weighted impact

References

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100%

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Citations per year

Cited by

Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases