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Protease Inhibitors:  Current Status and Future Prospects

Journal of Medicinal Chemistry · 2000 · Vol. 43(3) · pp. 305–341
Donmienne LeungGiovanni AbbenanteDavid P. Fairlie

Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTProtease Inhibitors: Current Status and Future ProspectsDonmienne Leung, Giovanni Abbenante, and David P. FairlieView Author Information Centre for Drug Design and Development, University of Queensland, Brisbane, Queensland 4072, Australia Cite this: J. Med. Chem. 2000, 43, 3, 305–341Publication Date (Web):February 10, 2000Publication History Received12 August 1999Published online10 February 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/jm990412mhttps://doi.org/10.1021/jm990412mreview-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views9760Altmetric-Citations748LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Inhibitors,Monomers,Peptides and proteins,Reaction products Get e-Alerts

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor MechanismsPeptidase Inhibition and AnalysisCitationIconSocial mediaComputer scienceLibrary scienceWorld Wide WebInformation retrieval

MeSH terms

AnimalsCysteine EndopeptidasesHumansMetalloendopeptidasesModels, MolecularProtease InhibitorsSerine EndopeptidasesSerine Proteinase InhibitorsCysteine Proteinase InhibitorsAspartic Acid Endopeptidases
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References
Caspases: the executioners of apoptosis
Biochemical Journal · 1997 · 4,725 citations
On the size of the active site in proteases. I. Papain
Biochemical and Biophysical Research Communications · 1967 · 5,205 citations
Peptidomimetics—Tailored Enzyme Inhibitors
Angewandte Chemie International Edition in English · 1994 · 816 citations
The Pathophysiology of Tumor Necrosis Factors
Annual Review of Immunology · 1992 · 1,880 citations
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