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Psoriasis Triggered by Toll-like Receptor 7 Agonist Imiquimod in the Presence of Dermal Plasmacytoid Dendritic Cell Precursors

Archives of Dermatology · 2004 · Vol. 140(12) · pp. 1490–5

Michel Gilliet✉(University Hospital of Zurich)Curdin ConradMichael L. GeigesAntonio CozzioWolfgang ThürlimannGünter BurgFrank O. NestléReinhard Dummer

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Abstract

This study shows that psoriasis can be driven by the innate immune system through TLR ligation. Furthermore, our finding that large numbers of PDCs infiltrate psoriatic skin suggests a role of lesional PDCs as type I interferon-producing targets for the TLR7 agonist imiquimod.

Immunotherapy and Immune Responses T-cell and B-cell Immunology Immune Response and InflammationTLR7ImiquimodPlasmacytoid dendritic cellPsoriasisMedicineImmunologyInterferonInnate immune systemToll-like receptorDendritic cell

MeSH terms

ImiquimodAdministration, TopicalAminoquinolinesBiopsyDendritic CellsDiagnostic ErrorsFluorescent Antibody TechniqueHumansImmunohistochemistryInterferon InducersMaleMembrane GlycoproteinsMiddle AgedPlasma CellsPsoriasis

Citations

404

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4.56

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95%

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