reviewTop 1% cited
The history and future of targeting cyclin-dependent kinases in cancer therapy
Nature Reviews Drug Discovery · 2015 · Vol. 14(2) · pp. 130–146
Uzma Asghar✉(Institute of Cancer Research)Agnieszka K. Witkiewicz(Harold C. Simmons Comprehensive Cancer Center)Nicholas C. Turner(Royal Marsden NHS Foundation Trust)Erik S. Knudsen(The University of Texas Southwestern Medical Center)
Advanced Breast Cancer TherapiesCancer-related Molecular PathwaysMicrotubule and mitosis dynamicsKinaseCyclinCancer researchTargeted therapyCancerCyclin-dependent kinaseCancer therapyMedicineOncologyBiology
MeSH terms
AnimalsAntineoplastic AgentsCell CycleClinical Trials as TopicDrug Evaluation, PreclinicalHumansNeoplasmsMolecular StructureSignal TransductionGene Expression Regulation, NeoplasticCyclin-Dependent KinasesDrug DiscoveryMolecular Targeted Therapy
Funding
- Bristol-Myers Squibb
- F. Hoffmann-La Roche
- Consortium canadien en neurodégénérescence associée au vieillissement
- National Cancer Institute
Citations
1,738
FWCI
112.17
field-weighted impact
References
212
Percentile
100%
vs. same field & year
Citations per year
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Development · 2013 · 1,469 citations
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Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis
Developmental Cell · 2010 · 849 citations
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
Cell · 1997 · 5,018 citations
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
Genes & Development · 1998 · 2,108 citations
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