article Open AccessTop 1% cited
Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
Cancer Cell · 2012 · Vol. 21(3) · pp. 418–429
Paolo P. Provenzano✉(Fred Hutch Cancer Center)Carlos Cuevas(University of Washington)Amy Chang(Fred Hutch Cancer Center)Vikas Goel(Fred Hutch Cancer Center)Daniel D. Von Hoff(Translational Genomics Research Institute)Sunil R. Hingorani(University of Washington Medical Center)
Pancreatic and Hepatic Oncology ResearchProteoglycans and glycosaminoglycans researchFibroblast Growth Factor ResearchStromaGemcitabineStromal cellCancer researchInterstitial fluidHyaluronic acidPancreatic cancerTumor microenvironmentPerfusionChemistry
MeSH terms
GemcitabineAdenocarcinomaAnimalsAntineoplastic Combined Chemotherapy ProtocolsDeoxycytidineDrug Evaluation, PreclinicalHyaluronic AcidHyaluronoglucosaminidasePancreatic NeoplasmsPolyethylene GlycolsCell Adhesion MoleculesStromal CellsCarcinoma, Pancreatic DuctalAnimals, Genetically ModifiedExtracellular Fluid
Funding
- Giles W. and Elise G. Mead Foundation
- Fred Hutchinson Cancer Research Center
- Halozyme
- National Cancer Institute
Citations
2,074
FWCI
56.54
field-weighted impact
References
68
Percentile
100%
vs. same field & year
Citations per year
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References
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Cancer Cell · 2005 · 2,599 citations
Putting tumours in context
Nature reviews. Cancer · 2001 · 2,159 citations
High interstitial fluid pressure — an obstacle in cancer therapy
Nature reviews. Cancer · 2004 · 2,134 citations
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Cancer Cell · 2003 · 2,460 citations
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The Journal of Physiology · 1896 · 2,135 citations
Hyaluronan: from extracellular glue to pericellular cue
Nature reviews. Cancer · 2004 · 2,103 citations
A Physical Interpretation of the Phenomenological Coefficients of Membrane Permeability
The Journal of General Physiology · 1961 · 712 citations
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