article Open AccessTop 1% cited
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Cancer Cell · 2005 · Vol. 7(5) · pp. 469–483
Sunil R. Hingorani✉(Cancer Research Institute)Lifu Wang(UPMC Hillman Cancer Center)Asha S. Multani(The University of Texas MD Anderson Cancer Center)Chelsea Combs(University of Pennsylvania)Thérèse B. Deramaudt(University of Pennsylvania)Ralph H. Hruban(Cancer Research Center)Anil K. Rustgi(University of Pennsylvania)Sandy Chang(The University of Texas MD Anderson Cancer Center)David A. Tuveson✉(Cancer Research Institute)
Pancreatic and Hepatic Oncology ResearchEpigenetics and DNA MethylationCancer Genomics and DiagnosticsChromosome instabilityBiologyCancer researchAdenocarcinomaPancreasGenome instabilityChromosomal translocationSuppressorPathogenesisPancreatic cancer
MeSH terms
AnimalsChromosome AberrationsGene Expression RegulationMice, Inbred C57BLMice, Inbred StrainsMice, Mutant StrainsMice, TransgenicNeoplasm MetastasisTranslocation, GeneticGene RearrangementTrans-ActivatorsCadherinsGene ExpressionSurvival AnalysisGenes, Tumor Suppressor
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