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Structural Basis of the Drug-binding Specificity of Human Serum Albumin

Journal of Molecular Biology · 2005 · Vol. 353(1) · pp. 38–52

J. Ghuman(Imperial College London)Patricia A. Zunszain(Imperial College London)I. Petitpas(Imperial College London)Ananyo A. Bhattacharya(Imperial College London)Masaki Otagiri(Kumamoto University)Stephen Curry✉(Imperial College London)

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Protein Interaction Studies and Fluorescence Analysis Monoclonal and Polyclonal Antibodies Research Drug Transport and Resistance MechanismsHuman serum albuminDrugPlasma protein bindingChemistryBinding siteBiochemistryDrug discoveryAlbuminSerum albuminComputational biology

MeSH terms

Binding SitesPharmaceutical PreparationsHumansLigandsModels, MolecularProtein BindingSerum AlbuminStructure-Activity RelationshipSubstrate SpecificityProtein Structure, TertiaryCrystallography, X-RayMyristic Acid

Funding

Wellcome Trust
Medical Research Council
Biotechnology and Biological Sciences Research Council
Deutsches Elektronen-Synchrotron

Citations

1,885

FWCI

14.38

field-weighted impact

References

62

Percentile

99%

vs. same field & year

Citations per year

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References

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Medical Entomology and Zoology · 2002 · 18,132 citations

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Biochemical Pharmacology · 2002 · 545 citations

The Characterization of Two Specific Drug Binding Sites on Human Serum Albumin

Molecular Pharmacology · 1975 · 1,696 citations

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Molecular Pharmacology · 1976 · 1,435 citations

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