articleTop 10% cited
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2010 · Vol. 1807(6) · pp. 726–734
Cancer, Hypoxia, and MetabolismCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated ReceptorsGlycolysisOxidative phosphorylationBeta oxidationBiochemistryCancer cellProgrammed cell deathBiologyMitochondrionCell biologyFatty acid
MeSH terms
Adenosine TriphosphateBrain NeoplasmsDrug Evaluation, PreclinicalEpoxy CompoundsFatty AcidsGlioblastomaHumansHypoglycemic AgentsModels, BiologicalNADPOxidation-ReductionTumor Cells, CulturedDown-RegulationUp-RegulationCell Death
Citations
460
FWCI
4.06
field-weighted impact
References
39
Percentile
94%
vs. same field & year
Citations per year
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References
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Nature Reviews Drug Discovery · 2009 · 5,229 citations
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
Cell Metabolism · 2008 · 4,067 citations
Persistent oxidative stress in cancer
FEBS Letters · 1995 · 1,215 citations
On the Origin of Cancer Cells
Science · 1956 · 13,149 citations
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Science · 2009 · 15,796 citations
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
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GLUTATHIONE
Annual Review of Biochemistry · 1983 · 5,635 citations
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