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CTLA-4 can function as a negative regulator of T cell activation

Immunity · 1994 · Vol. 1(5) · pp. 405–413

Theresa L. Walunas✉(University of Chicago)Deborah J. Lenschow(University of Chicago)Christina Y. Bakker(University of Chicago)Peter S. Linsley(University of Chicago)Gordon J. Freeman(Bristol-Myers Squibb (United States))Jonathan M. Green(University of Chicago)Craig B. Thompson(Harvard University)Jeffrey A. Bluestone(University of Chicago)

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T-cell and B-cell Immunology Immune Cell Function and Interaction Monoclonal and Polyclonal Antibodies ResearchCD28CTLA-4T cellBiologyCell biologyRegulatorAntibodyAntigenCo-stimulationZAP70

MeSH terms

AbataceptAnimalsAntibodiesAntibodies, MonoclonalAntigens, DifferentiationBase SequenceCell DivisionHumansImmunoglobulin FragmentsImmunoglobulin Fab FragmentsLymphocyte Culture Test, MixedLymphocyte ActivationMaleMembrane ProteinsMice, Inbred BALB C

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References

CTLA-4 is a second receptor for the B cell activation antigen B7.

The Journal of Experimental Medicine · 1991 · 1,684 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

The Journal of Experimental Medicine · 1995 · 2,186 citations

CTLA-4 can function as a negative regulator of T cell activation

Immunity · 1994 · 2,184 citations

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