article Open AccessTop 1% cited
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
Cell stem cell · 2013 · Vol. 12(3) · pp. 329–341
Eleni D. Lagadinou(University of Rochester Medical Center)Alexander Sach(University of Rochester Medical Center)Kevin P. Callahan(University of Rochester Medical Center)Randall M. Rossi(University of Rochester Medical Center)Sarah J. Neering(University of Rochester Medical Center)Mohammad Minhajuddin(University of Rochester Medical Center)John M. Ashton(University of Rochester Medical Center)Shanshan Pei(University of Rochester Medical Center)Valerie Grose(University of Rochester Medical Center)Kristen M. O’Dwyer(University of Rochester Medical Center)Jane L. Liesveld(University of Rochester Medical Center)Paul S. Brookes(University of Rochester Medical Center)Michael W. Becker(University of Rochester Medical Center)Craig T. Jordan✉(University of Rochester Medical Center)
Acute Myeloid Leukemia ResearchCancer, Hypoxia, and MetabolismHistone Deacetylase Inhibitors ResearchOxidative phosphorylationReactive oxygen speciesBiologyOxidative stressStem cellLeukemiaPhosphorylationCancer researchCancer cellApoptosis
MeSH terms
HumansIndolesOxidative PhosphorylationPyrrolesTumor Cells, CulturedNeoplastic Stem CellsLeukemia, Myeloid, AcuteApoptosisReactive Oxygen SpeciesProto-Oncogene Proteins c-bcl-2
Funding
- Medical Center, University of Rochester
Citations
1,365
FWCI
34.83
field-weighted impact
References
26
Percentile
100%
vs. same field & year
Citations per year
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References
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Nature Reviews Drug Discovery · 2009 · 5,229 citations
The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
Cell stem cell · 2010 · 1,071 citations
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Cancer Cell · 2006 · 1,217 citations
Regulation of cancer cell metabolism
Nature reviews. Cancer · 2011 · 4,732 citations
On the Origin of Cancer Cells
Science · 1956 · 13,149 citations
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