article Open AccessTop 1% cited

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

Nature Cell Biology · 2014 · Vol. 16(10) · pp. 992–1003

Valerie S. LeBleu✉(The University of Texas MD Anderson Cancer Center)Joyce T. O’Connell(Beth Israel Deaconess Medical Center)Karina N. Gonzalez Herrera(Harvard University)Harriet Wikman(University Medical Center Hamburg-Eppendorf)Klaus Pantel(University Medical Center Hamburg-Eppendorf)Marcia C. Haigis(Harvard University)Fernanda Machado de Carvalho(AC Camargo Hospital)Aline Santos Damascena(AC Camargo Hospital)Ludmilla Thomé Domingos Chinen(AC Camargo Hospital)Rafael Malagoli Rocha(AC Camargo Hospital)John M. Asara(Beth Israel Deaconess Medical Center)Raghu Kalluri(Beth Israel Deaconess Medical Center)

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Cancer, Hypoxia, and Metabolism Adipose Tissue and Metabolism Peroxisome Proliferator-Activated ReceptorsMitochondrial biogenesisCancer cellMetastasisCoactivatorBiologyTFAMCancer researchCell biologyMitochondrionOxidative phosphorylation

MeSH terms

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnimalsBreast NeoplasmsCell MovementFemaleHumansImmunohistochemistryMaleMice, Inbred BALB CMice, Inbred C57BLMice, NudeMiddle AgedMitochondriaNeoplasm InvasivenessNeoplasm Metastasis

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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets