articleTop 1% cited
Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
Molecular Pharmacology · 2002 · Vol. 62(3) · pp. 638–646
Jodi M. Maglich✉(GlaxoSmithKline (United States))Catherine M. Stoltz(Research Triangle Park Foundation)Bryan Goodwin(GlaxoSmithKline (United States))Diane Hawkins-Brown(Research Triangle Park Foundation)John T. Moore(GlaxoSmithKline (United States))Steven A. Kliewer(Research Triangle Park Foundation)
Pharmacogenetics and Drug MetabolismHormonal Regulation and HypertensionEstrogen and related hormone effectsPregnane X receptorConstitutive androstane receptorXenobioticNuclear receptorAryl hydrocarbon receptorBiologyGeneDrug metabolismPregnaneReceptor
MeSH terms
Pregnane X ReceptorConstitutive Androstane ReceptorAnimalsAryl Hydrocarbon HydroxylasesCells, CulturedCytochrome P-450 Enzyme SystemGene Expression RegulationHumansIntestine, SmallLiverInactivation, MetabolicOxidation-ReductionReceptors, SteroidSteroid HydroxylasesTranscription Factors
Citations
648
FWCI
35.86
field-weighted impact
References
45
Percentile
100%
vs. same field & year
Citations per year
References
P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR
Archives of Biochemistry and Biophysics · 1999 · 762 citations
Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital
Molecular Pharmacology · 2002 · 466 citations
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Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
Molecular Pharmacology · 2002 · 648 citations
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