articleTop 1% cited

Using the Golden Triangle to optimize clearance and oral absorption

Bioorganic & Medicinal Chemistry Letters · 2009 · Vol. 19(19) · pp. 5560–5564

Ted W. Johnson✉(Pfizer (United States))Klaus Dress(Pfizer (United States))Martin P. Edwards(Pfizer (United States))

Computational Drug Discovery Methods Pharmacogenetics and Drug Metabolism Analytical Chemistry and ChromatographyChemistryOctanolPotencyPartition coefficientPermeability (electromagnetism)In vitroChromatographyStereochemistryBiochemistryMembrane

MeSH terms

AbsorptionAdministration, OralPharmaceutical PreparationsHumansMetabolic Clearance RateMicrosomes, LiverMolecular WeightOrganic ChemicalsPermeabilityDrug DesignCaco-2 Cells

Citations

368

FWCI

17.75

field-weighted impact

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100%

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References

In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth

Pharmaceutical Research · 1997 · 1,012 citations

Physiochemical drug properties associated with in vivo toxicological outcomes

Bioorganic & Medicinal Chemistry Letters · 2008 · 954 citations

Targeting multidrug resistance in cancer

Nature Reviews Drug Discovery · 2006 · 3,630 citations

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Nature Reviews Drug Discovery · 2007 · 2,269 citations

Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1

Advanced Drug Delivery Reviews · 2001 · 1,524 citations

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Journal of Medicinal Chemistry · 2002 · 7,875 citations

Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability

Bioorganic & Medicinal Chemistry Letters · 2009 · 318 citations

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

Journal of Medicinal Chemistry · 2008 · 940 citations

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