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Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis (NASH) Patients: A Connection Between Endogenous Alcohol and NASH
Hepatology · 2012 · Vol. 57(2) · pp. 601–609
Lixin Zhu(University at Buffalo, State University of New York)Susan S. Baker✉(GTx (United States))Chelsea Gill(University of Rochester)Wensheng Liu(University at Buffalo, State University of New York)Razan Alkhouri(University at Buffalo, State University of New York)Robert D. Baker(University at Buffalo, State University of New York)Steven R. Gill(University of Rochester)
Abstract
The increased abundance of alcohol-producing bacteria in NASH microbiomes, elevated blood-ethanol concentration in NASH patients, and the well-established role of alcohol metabolism in oxidative stress and, consequently, liver inflammation suggest a role for alcohol-producing microbiota in the pathogenesis of NASH. We postulate that the distinct composition of the gut microbiome among NASH, obese, and healthy controls could offer a target for intervention or a marker for disease.
Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health EffectsGut microbiota and healthMicrobiomeSteatohepatitisBiologyNonalcoholic steatohepatitisNonalcoholic fatty liver diseaseGut floraInternal medicineFatty liverEndocrinologyMedicine
MeSH terms
AdolescentEthanolBacteroidesChildFatty LiverFemaleHumansMaleObesityRNA, Ribosomal, 16SPrevotellaProteobacteriaGastrointestinal TractMetagenomeNon-alcoholic Fatty Liver Disease
Funding
- Centers for Disease Control and Prevention
Citations
1,681
FWCI
30.81
field-weighted impact
References
57
Percentile
100%
vs. same field & year
Citations per year
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