article Open AccessTop 1% cited
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease†
Hepatology · 2009 · Vol. 49(6) · pp. 1877–1887
Luca Miele(Università Cattolica del Sacro Cuore)Venanzio Valenza(Università Cattolica del Sacro Cuore)Giuseppe La TorreMassimo Montalto(Università Cattolica del Sacro Cuore)Giovanni Cammarota(Università Cattolica del Sacro Cuore)Riccardo Ricci(Università Cattolica del Sacro Cuore)R. Mascianà(Università Cattolica del Sacro Cuore)Alessandra Forgione(Università Cattolica del Sacro Cuore)M.L. Gabrieli(Università Cattolica del Sacro Cuore)Germano Perotti(Università Cattolica del Sacro Cuore)Fabio Maria Vecchio(Università Cattolica del Sacro Cuore)G.L. Rapaccini(Università Cattolica del Sacro Cuore)Antonio Gasbarrini(Università Cattolica del Sacro Cuore)Chris Day(Newcastle University)Antonio Grieco✉(Università Cattolica del Sacro Cuore)
Abstract
Our results provide the first evidence that NAFLD in humans is associated with increased gut permeability and that this abnormality is related to the increased prevalence of SIBO in these patients. The increased permeability appears to be caused by disruption of intercellular tight junctions in the intestine, and it may play an important role in the pathogenesis of hepatic fat deposition.
Liver Disease Diagnosis and TreatmentGut microbiota and healthDiet and metabolism studiesIntestinal permeabilityGastroenterologyInternal medicineTight junctionNonalcoholic fatty liver diseasePathogenesisSteatosisSmall intestinal bacterial overgrowthMedicineFatty liver
MeSH terms
AdultFatty LiverFemaleHumansIntestine, SmallMaleMiddle AgedPermeabilityTight Junctions
Funding
- Ministero dell’Istruzione, dell’Università e della Ricerca
Citations
1,403
FWCI
23.72
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References
47
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100%
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