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BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
Journal of Bone and Mineral Research · 2003 · Vol. 18(10) · pp. 1842–1853
Abstract
Our data strongly suggest that the capacity of BMP-2 and Shh to induce ALP relies on Wnt expression and the Wnt/LRP5 signaling cascade. Moreover the effects of BMP-2 on extracellular matrix mineralization by osteoblasts are mediated, at least in part, by the induction of a Wnt autocrine/paracrine loop. These results may help to explain the phenotype of OPPG patients and HBM.
Wnt/β-catenin signaling in development and cancerConnective tissue disorders researchCancer-related gene regulationWnt signaling pathwayOsteoblastLRP5Autocrine signallingNogginDKK1Cell biologyChemistryBone morphogenetic protein 2Alkaline phosphatase
MeSH terms
Alkaline PhosphataseAnimalsAzo CompoundsCell DifferentiationCell DivisionCell LineCells, CulturedCycloheximideCytoskeletal ProteinsDose-Response Relationship, DrugColoring AgentsLuciferasesMice, Inbred C3HModels, BiologicalOsteoblasts
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763
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55
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