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Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

American Journal Of Pathology · 2009 · Vol. 176(1) · pp. 85–97

Benjamin D. Humphreys(Brigham and Women's Hospital)Shuei‐Liong Lin(Brigham and Women's Hospital)Akio Kobayashi(Harvard University)Thomas E. Hudson(Brigham and Women's Hospital)Brian T. Nowlin(Brigham and Women's Hospital)Joseph V. Bonventre(Brigham and Women's Hospital)M. Todd Valerius(Harvard University)Andrew P. McMahon(Harvard University)Jeremy S. Duffield✉(Brigham and Women's Hospital)

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Renal and related cancers Chronic Kidney Disease and Diabetes Renal cell carcinoma treatmentMyofibroblastFibrosisPathologyPericyteKidneyBiologyMedicineGenetics

MeSH terms

S100 Calcium-Binding Protein A4ActinsAnimalsCell MovementCells, CulturedDisease Models, AnimalEpithelial CellsFibroblastsFibrosisKidneyKidney TubulesMesodermS100 ProteinsPromoter Regions, GeneticTranscription Factors

Funding

American Society of Nephrology
Massachusetts General Hospital
National Science Council
National Institutes of Health
Harvard Stem Cell Institute

Citations

1,398

FWCI

33.08

field-weighted impact

References

66

Percentile

100%

vs. same field & year

Citations per year

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References

Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development

Cell stem cell · 2008 · 962 citations

Intrinsic Epithelial Cells Repair the Kidney after Injury

Cell stem cell · 2008 · 861 citations

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

American Journal Of Pathology · 2008 · 834 citations

Epithelial-mesenchymal transition and its implications for fibrosis

Journal of Clinical Investigation · 2003 · 2,289 citations

TGF-β and epithelial-to-mesenchymal transitions

Oncogene · 2005 · 1,577 citations

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Journal of Clinical Investigation · 2002 · 1,813 citations

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

Cell stem cell · 2008 · 3,949 citations

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

Journal of the American Society of Nephrology · 2008 · 853 citations

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Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis · Scinovex