article Open AccessTop 1% cited
Cannabidiol displays unexpectedly high potency as an antagonist of CB<sub>1</sub>and CB<sub>2</sub>receptor agonists<i>in vitro</i>
British Journal of Pharmacology · 2007 · Vol. 150(5) · pp. 613–623
Adèle Thomas✉(University of Aberdeen)Gemma L. Baillie(University of Aberdeen)Angela M. Phillips(University of Aberdeen)Raj K. Razdan(Organix (United States))Ruth A. Ross(University of Aberdeen)Roger G. Pertwee(University of Aberdeen)
Abstract
This study has provided the first evidence that cannabidiol can display CB2 receptor inverse agonism, an action that appears to be responsible for its antagonism of CP55940 at the human CB2 receptor. The ability of cannabidiol to behave as a CB2 receptor inverse agonist may contribute to its documented anti-inflammatory properties.
Cannabis and Cannabinoid ResearchDiet, Metabolism, and DiseaseNeurotransmitter Receptor Influence on BehaviorCannabidiolInverse agonistCannabinoidPharmacologyCannabinoid receptorCannabinoid receptor type 2ReceptorAgonistChemistryCannabinoid receptor antagonist
MeSH terms
RimonabantAnimalsAnti-Inflammatory AgentsCamphanesBrainCannabidiolCell MembraneCricetulusCyclohexanesCyclohexanolsDose-Response Relationship, DrugCricetinaeHumansMice, Inbred C57BLMorpholines
Funding
- GW Pharmaceuticals
- Biotechnology and Biological Sciences Research Council
Citations
744
FWCI
18.31
field-weighted impact
References
28
Percentile
100%
vs. same field & year
Citations per year
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References
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Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
British Journal of Pharmacology · 2001 · 1,289 citations
Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Biochemical Pharmacology · 1973 · 12,855 citations
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