article Open AccessTop 1% cited
The orphan receptor GPR55 is a novel cannabinoid receptor
British Journal of Pharmacology · 2007 · Vol. 152(7) · pp. 1092–1101
Erik Ryberg(AstraZeneca (Sweden))Niklas Larsson(AstraZeneca (Sweden))S. Sjögren(AstraZeneca (Sweden))Stephan Hjorth(AstraZeneca (Sweden))Nils-Olov Hermansson(AstraZeneca (Sweden))J Leonova(AstraZeneca (Sweden))Thomas Elebring(AstraZeneca (Sweden))Peter Nilsson(AstraZeneca (Sweden))Tomáš Drmota(AstraZeneca (Sweden))Peter J. Greasley✉(AstraZeneca (Sweden))
Abstract
These data suggest that GPR55 is a novel cannabinoid receptor, and its ligand profile with respect to CB1 and CB2 described here will permit delineation of its physiological function(s).
Cannabis and Cannabinoid ResearchPancreatic function and diabetesSleep and Wakefulness ResearchCannabinoid receptorCannabinoidGPR18Cannabinoid receptor type 2Endocannabinoid systemGTPgammaSChemistryReceptorPharmacologyBiology
MeSH terms
Amino Acid SequenceAnimalsArachidonic AcidsBinding SitesBinding, CompetitiveCannabidiolCannabinoidsCell LineCloning, MolecularCyclohexanolsHumansLigandsMolecular Sequence DataOrgan SpecificityRNA, Messenger
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