article Open AccessTop 10% cited

The adaptive evolution of the mammalian mitochondrial genome

BMC Genomics · 2008 · Vol. 9(1) · pp. 119–119

Rute R. da Fonseca✉(Rede de Química e Tecnologia)Warren E. Johnson(National Cancer Institute)Stephen J. O’Brien(National Cancer Institute)Maria J. Ramos(Universidade do Porto)Agostinho Antunes(National Cancer Institute)

View via DOI Full-text PDF

Abstract

Our study provides insight into the adaptive evolution of the mtDNA genome in mammals and its implications for the molecular mechanism of oxidative phosphorylation. We present a framework for future experimental characterization of the impact of specific mutations in the function, physiology, and interactions of the mtDNA encoded proteins involved in oxidative phosphorylation.

Mitochondrial Function and Pathology Genomics and Phylogenetic Studies Physiological and biochemical adaptationsBiologyMitochondrial DNACytochrome c oxidaseMitochondrionAdaptation (eye)Oxidative phosphorylationEvolutionary biologyGenomeGeneProtein subunit

MeSH terms

Adaptation, PhysiologicalAerobiosisAmino Acid SequenceAnimalsBasal MetabolismHumansMitochondriaModels, MolecularMutationNADH DehydrogenaseOxidative PhosphorylationOxygenPhylogenyProtein Structure, SecondaryEvolution, Molecular